Pacific Biosciences is based in the heart of Silicon Valley and provides sophisticated genomic sequencing and analysis systems that deliver invaluable insights for scientists who strive to resolve complex genetic challenges.  Harnessing advances in biochemistry, optics, nanofabrication, and more, PacBio developed Single Molecule, Real-Time (SMRT) Sequencing technology. This powerful technology enables real-time analysis of biomolecules with single-molecule resolution.

PacBio sequencing offers the most comprehensive view of genomes, transcriptomes, and epigenomes — including the full spectrum of genetic variation — by providing the longest average read lengths, highest consensus accuracy, and most uniform coverage of any sequencing technology on the market today. Ideal for de novo genome assembly and genetic variation characterization of humansanimals, plants, and microbes, this system features high-performance optics, automated liquid handling, and an intuitive, intelligent operating system.

The Sequel II System: 

Setting a New Standard in Long-Read Sequencing, the Sequel II system has been recognized for its ability to generate longer reads with greater accuracy and throughput, at a significantly lower cost.

Delivering Highly Accurate Long Reads 

The Sequel II System provides the advantages of SMRT Sequencing and now makes it more affordable for all scientists to drive discovery with comprehensive views of genomes and transcriptomes.

  • Produces the exceptional results customers have come to expect from PacBio Systems
  • Generates ~8-times more data than the original Sequel System
  • Provides access to even more highly accurate long reads (HiFi reads) – Learn more about HiFi reads
  • Reduces project time for faster results
  • Makes sequencing more affordable
  • Supports the range of SMRT Sequencing applications

Get to know the Sequel II System and its cost-effective sequencing applications with our Interactive Brochure

Explore our latest system release

Sequel II System Consumables including the SMRT Cell 8M

Introducing the new Sequel II Consumables to empower your research to the next level. Starting with the SMRT Cell 8M which contains approximately 8 million ZMWs to increase the sequencing throughput by ~8-fold. In addition to the SMRT Cell 8M, Sequel II Consumables consist of Sequel II Binding and Internal Control Kit 1.0 and Sequel II Sequencing Kit 1.0. Learn how these new consumables can elevate your whole genome sequencingvariant detection, and full-length RNA sequencing research with quick turnaround times to characterize SNPs, structural variants, splice isoforms, and improved genome annotation with high accuracy.

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